Melrose Park offers a somewhat walkable environment, with certain areas being more accessible on foot than others. Sidewalks and basic walking infrastructure are present, allowing for moderate ease in navigating the area. However, the spread-out nature of some destinations may require longer walks, making it less convenient for accessing all locations. Weather conditions, typical of the Midwest, can also influence the comfort of walking, especially during extreme seasons. While walking can be a practical option for short distances or specific neighborhoods, other transportation methods may be more suitable for reaching farther destinations.

Cycling in Melrose Park is supported by moderate biking opportunities, with some infrastructure in place to assist cyclists. The area is generally bikeable, and many destinations are accessible by bicycle, though the ease of biking may vary depending on specific routes and distances. Roadways in the region are being improved to support alternative transportation, including biking. However, riders should consider factors like traffic and the layout of streets when planning their trips.

For those relying on public transit, Melrose Park includes options such as the Pace Bus service, which connects the area to nearby transit hubs like the CTA Blue Line Forest Park Transit Center. This allows for further connections to Chicago and surrounding areas. The infrastructure supports bus travel with stops and routes that link key destinations. However, the suburban layout and distances between locations may make walking to transit stops less convenient for some. Public transit can be a practical choice for those traveling to nearby areas, but local trips may require additional planning due to the spread-out nature of the region.