La Serena features a pedestrian-friendly environment, with its compact city center making many attractions accessible on foot. The colonial architecture, plazas, and nearby beaches are within reasonable walking distances, allowing visitors to explore comfortably. The region’s mild, pleasant weather further supports walking as a practical option. However, some destinations, particularly those outside the central area or in the surrounding valleys, may require alternative transportation due to greater distances. Overall, walking is a convenient way to navigate the central parts of La Serena while enjoying its scenic and historical charm.

Cycling in La Serena is supported by a bike-friendly environment with some dedicated cycling paths, such as those connecting El Faro to Playa La Barca and Los Corsarios to Coquimbo. These routes make it easier to navigate certain areas by bicycle, especially along the coastline. The relatively flat terrain in many parts of the city supports biking as a practical option. However, the availability of bike lanes may vary across neighborhoods, so planning routes in advance is recommended. The mild climate generally provides comfortable conditions for cycling throughout the year.

Getting around La Serena by public transportation is facilitated by a network of buses that connect various neighborhoods and key attractions. The infrastructure supports accessibility to many areas, and buses are a cost-effective choice for travelers. The relatively mild weather in the region generally allows for comfortable transit conditions. However, the efficiency of public transit may vary depending on the distance and specific destinations, so planning routes in advance is recommended to ensure smooth travel.