La Serena features a pedestrian-friendly environment, with its compact city center making many attractions accessible on foot. The colonial architecture, plazas, and nearby beaches are within reasonable walking distances, allowing visitors to explore comfortably. The region’s mild, pleasant weather further supports walking as a practical option. However, some destinations, particularly those outside the central area or in the surrounding valleys, may require alternative transportation due to greater distances. Overall, walking is a convenient way to navigate the central parts of La Serena while enjoying its scenic and historical charm.

Le vélo à La Serena bénéficie d'un environnement adapté aux vélos avec des pistes cyclables, comme celles qui relient El Lo à Play La Barca et Los Corsarios à Coquiambo. Ces itinéraires facilitent la navigation dans certaines régions à vélo, en particulier le long de la côte. Étant donné que le terrain est relativement plat dans de nombreuses parties de la ville, la location de vélos est une option pratique. Cependant, la disponibilité des pistes cyclables peut varier d'un quartier à l'autre. Il est donc recommandé de planifier les itinéraires à l'avance. Le climat frais offre généralement des conditions confortables pour le vélo tout au long de l'année.

Getting around La Serena by public transportation is facilitated by a network of buses that connect various neighborhoods and key attractions. The infrastructure supports accessibility to many areas, and buses are a cost-effective choice for travelers. The relatively mild weather in the region generally allows for comfortable transit conditions. However, the efficiency of public transit may vary depending on the distance and specific destinations, so planning routes in advance is recommended to ensure smooth travel.