La Serena features a pedestrian-friendly environment, with its compact city center making many attractions accessible on foot. The colonial architecture, plazas, and nearby beaches are within reasonable walking distances, allowing visitors to explore comfortably. The region’s mild, pleasant weather further supports walking as a practical option. However, some destinations, particularly those outside the central area or in the surrounding valleys, may require alternative transportation due to greater distances. Overall, walking is a convenient way to navigate the central parts of La Serena while enjoying its scenic and historical charm.

Andar de bicicleta em La Secena é ideal para bicicletas, com algumas ciclovias exclusivas, como a que liga El Faro à Playa La Barca e a Los Corsarios a Coquimbo. Esses trajetos facilitam o deslocamento de bicicletas em determinadas áreas, especialmente ao longo da orla. O piso plano em muitas partes da cidade favorece o uso da bicicleta como uma opção prática. No entanto, a disponibilidade de ciclovias pode variar conforme a região, por isso, é recomendável planejar os trajetos com antecedência. O clima leve geralmente oferece condições confortáveis para andar de bicicleta ao longo do ano.

Getting around La Serena by public transportation is facilitated by a network of buses that connect various neighborhoods and key attractions. The infrastructure supports accessibility to many areas, and buses are a cost-effective choice for travelers. The relatively mild weather in the region generally allows for comfortable transit conditions. However, the efficiency of public transit may vary depending on the distance and specific destinations, so planning routes in advance is recommended to ensure smooth travel.