聖塔安納擁有多個適合步行的區域，特別是在市中心，當地完善的行人設施與緊湊的街區規劃，讓人們能輕鬆步行前往商店、餐廳及文化景點。不過，各區的步行便利性有所不同，有些社區因距離較遠或人行設施有限而較難步行抵達。當地天氣普遍溫和宜人，適合全年大部分時間步行。雖然步行是探索聖塔安納部分地區的便利方式，但對於距離較遠或連通性較差的區域，步行未必是最實用的選擇。

Biking in Santa Ana comes with a mix of opportunities and challenges. The Santa Ana River Trail is a notable option, providing a dedicated path for cyclists away from traffic. However, bike lanes on city streets can be limited in some areas, and navigating busy roads may require caution. The relatively flat terrain makes biking manageable, but distances between destinations could vary. Weather conditions are generally favorable for biking, with mild temperatures and minimal rain.

Public transportation in Santa Ana provides accessible and convenient options for getting around the city. The Orange County Transportation Authority operates buses that connect key areas, and the Santa Ana Regional Transportation Intermodal Center serves as a hub for buses and trains, including Metrolink services. Public transit can be a practical choice for reaching many destinations, though the ease of use may depend on the distance and specific routes. The city’s infrastructure supports these options, but factors like walking distances to stops and the overall layout of the area may influence preferences.