Santa Ana cuenta con una combinación de áreas peatonales, especialmente en el distrito del centro, donde la infraestructura para peatones y los diseños compactos facilitan el acceso a pie a tiendas, restaurantes y atracciones culturales. Sin embargo, la accesibilidad para peatones varía en la ciudad, y algunos vecindarios son menos accesibles debido a la distancia o a una infraestructura peatonal limitada. El clima suele ser templado y agradable, por lo que caminar es una opción cómoda durante gran parte del año. Si bien caminar puede ser una manera conveniente de explorar ciertas partes de Santa Ana, puede que no siempre sea la opción más práctica para distancias más largas o áreas con menos conectividad.

Biking in Santa Ana comes with a mix of opportunities and challenges. The Santa Ana River Trail is a notable option, providing a dedicated path for cyclists away from traffic. However, bike lanes on city streets can be limited in some areas, and navigating busy roads may require caution. The relatively flat terrain makes biking manageable, but distances between destinations could vary. Weather conditions are generally favorable for biking, with mild temperatures and minimal rain.

Public transportation in Santa Ana provides accessible and convenient options for getting around the city. The Orange County Transportation Authority operates buses that connect key areas, and the Santa Ana Regional Transportation Intermodal Center serves as a hub for buses and trains, including Metrolink services. Public transit can be a practical choice for reaching many destinations, though the ease of use may depend on the distance and specific routes. The city’s infrastructure supports these options, but factors like walking distances to stops and the overall layout of the area may influence preferences.