聖安東尼奧有不少適合步行的地區，特別是在市中心和歷史區，這些地方的人行道和行人友善設施較為普及。該市的「完整街道計劃」旨在透過改善人行道、行人過路處和路緣斜坡，提升行人出行的便利和安全。不過，聖安東尼奧城市範圍廣闊，加上天氣炎熱，長距離步行未必吸引。雖然在部分社區步行是可行的，但整體體驗會因地區和季節而有所不同。

San Antonio offers a growing network of bike paths and lanes, making biking a practical way to explore the city. The city’s Bike Network Plan aims to improve safety and connectivity, linking neighborhoods, business districts, and recreational areas. The Howard Peak Greenway Trail network provides scenic routes for cyclists. While the weather can be warm, the infrastructure supports comfortable biking.

San Antonio’s public transportation system, primarily operated by the bus service, offers a cost-effective way to navigate the city. However, the infrastructure is more car-oriented, leading to challenges such as long waits and limited late-night service. While buses can efficiently connect certain areas, the need for multiple transfers can extend travel times significantly. The city’s expansive layout and underfunded transit system make driving a more convenient option for many, though public transit remains essential for those without access to a car.