Walking in Mount Pleasant can be an enjoyable way to explore certain areas, particularly those with pedestrian-friendly infrastructure. The town has made efforts to improve walkability through projects like designated pathways and greenways. However, the feasibility of walking as a primary mode of transportation may vary depending on the area. Some neighborhoods and commercial zones are more accessible on foot, while others may require navigating longer distances or less pedestrian-oriented infrastructure. Additionally, the warm and humid climate, especially during summer, might make walking less comfortable for extended periods.

Biking is a practical way to get around Mount Pleasant, supported by its growing network of bike-friendly paths and infrastructure. The area includes routes like the Mount Pleasant Way, which connects various parts of the town and provides safer biking options. However, some areas may require navigating busy roads or longer distances, which could be challenging for some riders. The generally mild weather supports year-round biking, though summer heat and humidity might make it less comfortable.

Mount Pleasanti ühistransport põhineb peamiselt bussiliinidel, mis ühendavad ka lähedal asuva Charlestoniga. Kuigi bussid võimaldavad ligipääsu mõnedele olulistele piirkondadele, võib linna ülesehitus ja äärelinna iseloom muuta kõikidesse sihtkohtadesse jõudmise vähem mugavaks. Hooajalised teenused, näiteks suvine buss Isle of Palmsile, võivad olla kasulikud konkreetsete sõitude jaoks. Siiski võib laialivalguv infrastruktuur ja võimalikud pikemad jalutuskäigud peatusteni muuta ühistranspordi igapäevasteks sõitudeks vähem praktiliseks võrreldes teiste võimalustega.