Walking in Guatemala City can be challenging due to its sprawling layout, limited pedestrian infrastructure, and safety concerns in certain areas. While some neighborhoods may be accessible on foot, distances between key destinations are often significant, making walking less practical for getting around the city as a whole. Additionally, uneven sidewalks and heavy traffic can pose obstacles. The weather, typically warm and humid, may also impact comfort during extended walks. For short distances within specific areas, walking can be an option, but it is advisable to plan routes carefully and remain aware of your surroundings.

由於專用的單車基礎設施有限, 且交通情況繁忙, 在危地馬拉城騎單車提出了挑戰。城市的佈局和交通擠塞情況, 可能會影響單車出行的便利性, 特別是在中部地區。此外, 本市部分地區地勢多山, 可能為單車者帶來困難。雖然單車短途或娛樂可能是一種選擇, 但當你計劃使用單車代步時, 務必要考慮安全問題, 以及現時缺乏適合單車行駛的道路。

危地馬拉市的公共交通系統包括 Transmetro，這是一個設有專用行車線的快速巴士系統，有助於減少主要路線的擠塞。此外，傳統的「雞巴士」亦廣泛運行，連接城市各區及鄰近地區。雖然這些選擇價格相宜且普及，但基礎設施有時會導致延誤，特別是在繁忙時段。城市的丘陵地形及交通情況亦可能影響行車時間。公共交通一般是穿梭市區的實用方式，但若需前往較遠或偏遠地區，則可能需要考慮其他交通方式。