La Serena features a pedestrian-friendly environment, with its compact city center making many attractions accessible on foot. The colonial architecture, plazas, and nearby beaches are within reasonable walking distances, allowing visitors to explore comfortably. The region’s mild, pleasant weather further supports walking as a practical option. However, some destinations, particularly those outside the central area or in the surrounding valleys, may require alternative transportation due to greater distances. Overall, walking is a convenient way to navigate the central parts of La Serena while enjoying its scenic and historical charm.

Biciklizam u La Sereni podupire okruženje prilagođeno biciklima s nekim namjenskim biciklističkim stazama, poput onih koje povezuju El Faro i Playa La Barca te Los Corsarios i Coquimbo. Te rute olakšavaju navigaciju biciklom u određenim područjima, posebice uz obalu. Relativno ravan teren u mnogim dijelovima grada podupire vožnju biciklom kao praktičnu opciju. Međutim, dostupnost biciklističkih staza može varirati u različitim četvrtima, pa se preporučuje planiranje ruta unaprijed. Blaga klima općenito pruža ugodne uvjete za vožnju biciklom tijekom cijele godine.

Getting around La Serena by public transportation is facilitated by a network of buses that connect various neighborhoods and key attractions. The infrastructure supports accessibility to many areas, and buses are a cost-effective choice for travelers. The relatively mild weather in the region generally allows for comfortable transit conditions. However, the efficiency of public transit may vary depending on the distance and specific destinations, so planning routes in advance is recommended to ensure smooth travel.