San Leandro provides a moderately walkable environment, with some areas featuring pedestrian-friendly infrastructure such as crosswalks and sidewalks. The city has made efforts to improve walkability, particularly in high-traffic zones, but certain areas may still require caution due to limited pedestrian amenities. The relatively mild weather in the region makes walking a comfortable option year-round. However, distances between key destinations may vary, so walking may be more practical for shorter trips within specific neighborhoods rather than for accessing the entire city.

Cycling in San Leandro is supported by a mix of biking infrastructure that makes it a viable transportation option. The city features bike lanes and paths, including connections to regional trails, which can make it easier to navigate certain areas by bicycle. However, the ease of biking may vary depending on the specific route, as some areas may have more limited bike-friendly infrastructure. The relatively mild terrain and accessible distances between key locations can make biking a practical choice for short to medium trips.

Public transportation in San Leandro offers several options, making it a practical choice for getting around the city and nearby areas. The Bay Area Rapid Transit (BART) system connects San Leandro to other parts of the Bay Area, with stations conveniently located in the city. AC Transit buses provide additional coverage, linking neighborhoods and nearby cities. The city also features shuttle services catering to specific groups, such as seniors and individuals with disabilities. Public transit is supported by accessible infrastructure, and the relatively mild weather in the region generally makes waiting for buses or trains comfortable.