La Serena features a pedestrian-friendly environment, with its compact city center making many attractions accessible on foot. The colonial architecture, plazas, and nearby beaches are within reasonable walking distances, allowing visitors to explore comfortably. The region’s mild, pleasant weather further supports walking as a practical option. However, some destinations, particularly those outside the central area or in the surrounding valleys, may require alternative transportation due to greater distances. Overall, walking is a convenient way to navigate the central parts of La Serena while enjoying its scenic and historical charm.

El ciclismo en La Serena está respaldado por un entorno apto para bicicletas con algunas rutas exclusivas para bicicletas, como las que conectan El Faro con Playa La Barca y Los Corsarios con Coquimbo. Estas rutas facilitan el recorrido en bicicleta por ciertas áreas, especialmente a lo largo de la costa. El terreno relativamente plano en muchas partes de la ciudad admite andar en bicicleta como una opción práctica. Sin embargo, la disponibilidad de los carriles para bicicletas puede variar según el vecindario, por lo que se recomienda planificar las rutas con anticipación. El clima templado generalmente proporciona condiciones cómodas para andar en bicicleta durante todo el año.

Getting around La Serena by public transportation is facilitated by a network of buses that connect various neighborhoods and key attractions. The infrastructure supports accessibility to many areas, and buses are a cost-effective choice for travelers. The relatively mild weather in the region generally allows for comfortable transit conditions. However, the efficiency of public transit may vary depending on the distance and specific destinations, so planning routes in advance is recommended to ensure smooth travel.