San Isidro offers a pleasant environment for walking, with tree-lined streets and a mix of residential and commercial areas. Many destinations, such as parks, shops, and cultural landmarks, are within a reasonable distance, making walking a convenient option for short trips. The area features pedestrian-friendly infrastructure, including sidewalks and crossings, though some streets may be quieter and less developed. The mild climate generally supports outdoor activities, though occasional rain or heat may affect comfort. Walking is a practical way to explore the charm of this suburban area while enjoying its relaxed atmosphere.

Biking in San Isidro is a practical option for navigating its mix of urban and suburban areas. The region features some bike-friendly infrastructure, including dedicated cycle lanes like those near the Tren de la Costa, which connects to San Isidro station. Many destinations are accessible by bike, and the relatively flat terrain supports comfortable rides. However, the suitability of biking may vary depending on specific routes and distances.

Public transportation in San Isidro provides straightforward options for getting around. The area is served by trains connecting it to Buenos Aires, as well as buses that provide access to local destinations. The infrastructure supports public transit with accessible stations and routes, though the cobblestone streets in some areas may require extra care when walking to stops. Public transportation is a practical choice for navigating the region, especially for those traveling between San Isidro and the city center.