Walking is an excellent way to explore Key West, as the island is compact and many attractions are within a short distance of each other. The flat terrain and pedestrian-friendly infrastructure, including sidewalks and crosswalks, make navigating on foot convenient. The tropical climate, however, can be hot and humid, especially during midday, so staying hydrated and wearing sun protection is essential. While most popular spots are easily accessible by walking, the heat or occasional rain showers might make walking less comfortable at times.

Biking is another practical way to get around Key West, with bike-friendly infrastructure, including designated bike lanes and racks throughout the area. Many popular destinations are easily accessible by bicycle due to the short distances between attractions. The flat terrain makes riding comfortable, though warm weather may require hydration and sun protection.

Public transit is a convenient option for navigating Key West, with bus routes like the Duval Loop providing easy access to popular areas such as Old Town and the historic district. The Lower Keys Shuttle connects Key West to nearby areas, making it a practical choice for exploring beyond the island. The compact size of Key West means many destinations are close together, and public transit is well-suited for short distances. However, the tropical climate may make waiting for buses less comfortable during hot or rainy conditions.

Ferries in Key West are primarily used for excursions rather than local transportation. For example, ferries connect Key West to the Dry Tortugas National Park, with daily sailings that are pedestrian-friendly and accommodate bicycles. These trips typically take about 2 hours each way. However, ferries do not serve as a primary mode of getting around Key West itself, as the island is compact and easily navigable by other means. Weather and sea conditions can occasionally impact ferry schedules, making them less predictable for regular commuting.