Walking is a practical way to explore Thessaloniki, as many key areas are compact and accessible on foot. The city features pedestrian-friendly infrastructure, particularly in central districts, where sidewalks and pathways are well-maintained. The relatively mild Mediterranean climate supports walking for much of the year, though summer heat may require precautions like staying hydrated. While the terrain is generally manageable, some areas may include slight inclines. Distances between major attractions and amenities are often short, making walking a convenient option for navigating the city’s vibrant streets and cultural landmarks.

Cycling in Thessaloniki presents some challenges due to limited dedicated biking infrastructure. While there are some temporary bike lanes, the lack of a comprehensive network may require cyclists to share roads with vehicles. The city’s relatively flat terrain in central areas can make biking manageable for short distances, but the overall infrastructure may not fully support extensive cycling.

塞薩洛尼基的公共交通系統主要依賴由塞薩洛尼基城市運輸組織（OASTH）營運的公車網絡。公車路線覆蓋範圍廣泛，使得前往城市大多數地區相對便利。然而，缺乏輕軌或無軌電車等其他運輸選項，可能在尖峰時段導致擁擠。城市基礎設施支援公車系統，但旅客應留意因交通狀況可能產生的延誤。對於熟悉公車時刻與路線的人來說，大眾運輸是遊覽塞薩洛尼基的實用選擇。