Walking is a practical way to explore Thessaloniki, as many key areas are compact and accessible on foot. The city features pedestrian-friendly infrastructure, particularly in central districts, where sidewalks and pathways are well-maintained. The relatively mild Mediterranean climate supports walking for much of the year, though summer heat may require precautions like staying hydrated. While the terrain is generally manageable, some areas may include slight inclines. Distances between major attractions and amenities are often short, making walking a convenient option for navigating the city’s vibrant streets and cultural landmarks.

Cycling in Thessaloniki presents some challenges due to limited dedicated biking infrastructure. While there are some temporary bike lanes, the lack of a comprehensive network may require cyclists to share roads with vehicles. The city’s relatively flat terrain in central areas can make biking manageable for short distances, but the overall infrastructure may not fully support extensive cycling.

塞薩洛尼基的公共交通系統主要依賴由塞薩洛尼基城市交通組織（OASTH）營運的巴士網絡。巴士覆蓋多條路線，讓大部分地區都較容易到達。不過，由於缺乏輕鐵或電車等其他交通選擇，高峰時段可能會出現擠塞。城市基建配合巴士系統運作，但旅客應留意交通可能導致延誤。公共交通對於熟悉巴士時間表和路線的人來說，是遊覽塞薩洛尼基的實用選擇。